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A recent meta-analysis found that E2 positively affects spatial memory in the Morris water maze in females, and E2 can potentiate the actions of GLP-1 on other centrally mediated behaviors, such as food intake and reward (57,58)

During menopause, declining oestrogen levels alter the body's temperature regulation, narrowing the thermoneutral zonethe temperature range within which the body maintains core temperature without triggering heat-loss mechanisms

They occurred more often in patients using Ozempic than in patients using placebos

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